在《奇奇与蒂蒂：救援突击队》电视动画结束30年后，奇奇成为了一个过着枯燥生活的保险业务员，蒂蒂则动了CGI手术让自己变成时下的3D动画造型，到处参加影迷活动回味着往日的辉煌；就在此时，针对动画人物的绑架事件接二连三的发生，当受害者中出现昔日同伴的名字时，奇奇与蒂蒂阔别多年的联手，试图找出真相与挽回破裂多年的友情。
演员: 安迪·萨姆伯格
/ John Mulaney
/ KiKi Layne
/ Will Arnett
/ Eric Bana
/ Flula Borg
/ Dennis Haysbert
/ Keegan-Michael Key
/ Tress MacNeille
/ Tim Robinson
/ Seth Rogen
/ J.K. Simmons
/ Da'Vone McDonald
/ Akiva Schaffer
/ Rachel Bloom
/ Juliet Donenfeld
/ Liz Cackowski
/ Mason Blomberg
/ Corey Burton
/ Jim Cummings
/ Chris Parnell
/ Jeff Bennett
/ June Schaffer
/ Steven Curtis Chapman
/ Jorma Taccone
/ Alan Oppenheimer
/ Hazel Schaffer
/ Charles Fleischer
/ Heather Dragulescu
/ Sean Rohani
/ Jake Matthew Cohen
/ Jonathan Verweij
/ Kai Zen
/ Sophie Fatu
/ Rachel Samiri
/ Matt Cook
/ Greg Chun
/ Tad Stones
/ Krystal Alvarez
/ Scott Whyte
/ Nneoma Sampson
/ Jean Gilpin
/ Jovana Lara
/ Victor Turpin
/ James Joseph Pulido
/ James M. Black
/ Kenzo Lee
/ J. Anthony McCarthy
/ David Tennant
/ Paula Abdul
/ Dan Gregor
/ 保罗·路德
/ Cole Massie
/ Jessie Hendricks
/ Philena Franklin
/ Rawson Marshall Thurber
/ Matt Nolan
/ Tom Antonellis
/ Doug Mand
/ Julian Graham
/ Anthony Molinari
